P-400 Fertility preservation in male patients with cancer: a systematic review and meta-analysis

Abstract Study question Whether the fertility preservation can benefit male patients with cancer. Summary answer Sperm cryopreservation is an effective method and may What known already only way to efficiently preserve fertility. It important procedure in assisted reproductive technologies (ART). Recently, due remarkable advances cancer treatment, increasing number of studies have reported outcomes sperm design, size, duration Systematic review meta-analysis summarize current evidence on 69 non-randomized were included meta-analysis. These 32,234 referred for analysis 23,178 whose was cryopreserved at least once. CENTRAL, CNKI, Cochrane Reviews, EMBASE, MEDLINE, PUBMED, Web Science searched from inception through December 31, 2021. Participants/materials, setting, methods All reporting offering or attempting cryopreserve before during treatment considered risk treatment-related impairment included. The pooled failed-to-cryopreserve, disposal use rate Meanwhile, pregnancy, miscarriage delivered rates after Main results role chance cryopreserving one sample. failed-to-cryopreserve 10% (95% confidence interval [CI], 8–12%), 23% CI, 16–30%) 9% 8–10%). miscarriage, delivery 28% 22–33%), 13% 10–17%), 20% 15–25%), respectively. Subgroup showed higher pregnancy a lower recent than older ones. Clinical per cycle 34% (27–41%), 24% (14–35%), (5–15%) (17–30%), 18% (11–26%), 5% (1–9%) ICSI, IVF, IUI, Limitations, reasons caution average obtained each study without patient-level data might represent first source bias. Furthermore, we did not analyze congenital abnormalities based because rarely reported. Wider implications findings Our supported previous reports that frozen our underestimated actual rate, making it meaningful actively recommend Trial registration applicable